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    ARP9 Arp9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855049, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARP9
    Official Full Name
    Arp9p
    Primary source
    SGD:S000004636
    Locus tag
    YMR033W
    See related
    AllianceGenome:SGD:S000004636; FungiDB:YMR033W; VEuPathDB:YMR033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RSC12; SWP59
    Summary
    Enables structural molecule activity. Involved in nucleosome organization; positive regulation of transcription by RNA polymerase II; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of RSC-type complex and SWI/SNF complex. Orthologous to human ACTL8 (actin like 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARP9 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (337788..339277)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene formin-binding protein HOF1 Neighboring gene uncharacterized protein Neighboring gene Rch1p Neighboring gene endopeptidase catalytic subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the full-length yeast Arp7-Arp9 heterodimer. Lobsiger J, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531465
    2. Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Cairns BR, et al. Mol Cell, 1998 Nov. PMID 9844636
    3. Allosteric interactions of DNA and nucleotides with S. cerevisiae RSC. Malik SS, et al. Biochemistry, 2011 Sep 20. PMID 21834590, Free PMC Article
    4. Structural insights into assembly and function of the RSC chromatin remodeling complex. Baker RW, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33288924, Free PMC Article
    5. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Turegun B, et al. Commun Biol, 2018. PMID 29809203, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a function for subunit Rtt102 as a stabilizing factor for the Arp7/9 heterodime
      Title: Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular non-membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arp9p
    NP_013747.1
    • Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      337788..339277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182530.1 → NP_013747.1  TPA: Arp9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZK8, Q05123
      UniProtKB/TrEMBL
      A6ZM95, B3LLT2, C7GL86, C8ZEP0, G2WK86, N1NX68
      Conserved Domains (1) summary
      COG5277
      Location:1 → 467
      COG5277; Actin-related protein [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05123.1

    Gene LinkOut

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