Myrip myosin VIIA and Rab interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myripprovided by RGD
Official Full Name: myosin VIIA and Rab interacting proteinprovided by RGD
Primary source: RGD:727731
See related: EnsemblRapid:ENSRNOG00000018797 AllianceGenome:RGD:727731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slac2c
Summary: Enables protein kinase A binding activity. Involved in positive regulation of insulin secretion. Located in apical plasma membrane; perinuclear region of cytoplasm; and secretory granule. Orthologous to human MYRIP (myosin VIIA and Rab interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 68.6), Lung (RPKM 45.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128895371..129062420)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (120017749..120184821)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128972307..129139257)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells
Title: The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Myrip (e-PCR), detects polymorphism
- UniSTS:259188

BF416406 (e-PCR)
- UniSTS:249277

BF416438 (e-PCR)
- UniSTS:249289

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab effector MyRIP

Names: exophilin-8; myosin-VIIa- and Rab-interacting protein; slaC2-c; slp homolog lacking C2 domains c; synaptotagmin-like protein lacking C2 domains C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182844.3 → NP_878264.2 rab effector MyRIP

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q7TNY7

UniProtKB/TrEMBL

D3ZTL2

Related

ENSRNOP00000025460.6, ENSRNOT00000025460.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

128895371..129062420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081681.2 → XP_038937609.1 rab effector MyRIP isoform X1

UniProtKB/Swiss-Prot

Q7TNY7

Related

ENSRNOP00000104715.1, ENSRNOT00000164781.1

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 882

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081687.2 → XP_038937615.1 rab effector MyRIP isoform X4

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 817

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081688.2 → XP_038937616.1 rab effector MyRIP isoform X5

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 125

FYVE_2; FYVE-type zinc finger

pfam04698
Location:152 → 791

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081682.2 → XP_038937610.1 rab effector MyRIP isoform X1

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 882

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081685.2 → XP_038937613.1 rab effector MyRIP isoform X1

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 882

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_063265675.1 → XP_063121745.1 rab effector MyRIP isoform X2

UniProtKB/Swiss-Prot

Q7TNY7

UniProtKB/TrEMBL

D3ZTL2
XM_039081683.2 → XP_038937611.1 rab effector MyRIP isoform X1

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 882

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081684.2 → XP_038937612.1 rab effector MyRIP isoform X1

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam02318
Location:8 → 151

FYVE_2; FYVE-type zinc finger

pfam04698
Location:178 → 882

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_063265676.1 → XP_063121746.1 rab effector MyRIP isoform X2

UniProtKB/Swiss-Prot

Q7TNY7

UniProtKB/TrEMBL

D3ZTL2
XM_039081686.2 → XP_038937614.1 rab effector MyRIP isoform X3

UniProtKB/Swiss-Prot

Q7TNY7

Conserved Domains (2) summary

pfam04698
Location:140 → 844

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

cl22851
Location:1 → 113

PHD_SF; PHD finger superfamily
XM_008766687.4 → XP_008764909.1 rab effector MyRIP isoform X6

See identical proteins and their annotated locations for XP_008764909.1

Conserved Domains (1) summary

pfam04698
Location:1 → 670

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
XM_039081689.2 → XP_038937617.1 rab effector MyRIP isoform X6

Conserved Domains (1) summary

pfam04698
Location:1 → 670

Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus