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    Med7 mediator complex subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911235, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Med7provided by RGD
    Official Full Name
    mediator complex subunit 7provided by RGD
    Primary source
    RGD:6494481
    See related
    EnsemblRapid:ENSRNOG00000007053 AllianceGenome:RGD:6494481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crsp9
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 56.2), Testes (RPKM 50.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med7 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (31343613..31359192)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30842330..30857873)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31532190..31536405)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene IL2-inducible T-cell kinase Neighboring gene golgi associated RAB2 interactor family member 3 Neighboring gene histidine-rich glycoprotein-like Neighboring gene hepatitis A virus cellular receptor 2 Neighboring gene hepatitis A virus cellular receptor 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Ryu S, et al. Nature, 1999 Feb 4. PMID 9989412
    2. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
    3. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    4. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
    5. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 7
    Names
    cofactor required for Sp1 transcriptional activation, subunit 9
    mediator of RNA polymerase II transcription subunit 7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286183.1 → NP_001273112.1  mediator of RNA polymerase II transcription subunit 7

      See identical proteins and their annotated locations for NP_001273112.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      31343613..31359192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085002.2 → XP_038940930.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Related
      ENSRNOP00000092450.1, ENSRNOT00000093900.2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    2. XM_063268249.1 → XP_063124319.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Related
      ENSRNOP00000079794.1, ENSRNOT00000119941.2

    3. XM_039085003.2 → XP_038940931.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Related
      ENSRNOP00000097914.1, ENSRNOT00000094962.2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    4. XM_039085004.2 → XP_038940932.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    5. XM_003750806.4 → XP_003750854.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_003750854.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    6. XM_006246161.4 → XP_006246223.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006246223.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    7. XM_063268247.1 → XP_063124317.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2

    8. XM_063268248.1 → XP_063124318.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2

    9. XM_039085006.2 → XP_038940934.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    10. XM_008767653.4 → XP_008765875.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_008765875.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    11. XM_006246158.5 → XP_006246220.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006246220.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    12. XM_003750804.4 → XP_003750852.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_003750852.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    13. XM_006246159.5 → XP_006246221.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006246221.1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    14. XM_039085007.2 → XP_038940935.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Related
      ENSRNOP00000009239.4, ENSRNOT00000009238.9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    15. XM_039085005.2 → XP_038940933.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      UniProtKB/TrEMBL
      A6HDR5, D4A7V2
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein
    Nucleotide Protein Strain
    Heading Accession and Version

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