U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cog5 component of oligomeric golgi complex 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314030, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cog5provided by RGD
    Official Full Name
    component of oligomeric golgi complex 5provided by RGD
    Primary source
    RGD:1563296
    See related
    EnsemblRapid:ENSRNOG00000056610 AllianceGenome:RGD:1563296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563296
    Summary
    Predicted to be involved in intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within inter-Golgi cisterna vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 158.5), Thymus (RPKM 105.4) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cog5 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53969967..54267869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48242470..48545185)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50953868..51230860)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene B-cell receptor-associated protein 29 Neighboring gene uncharacterized LOC134479362 Neighboring gene dihydrouridine synthase 4-like Neighboring gene G protein-coupled receptor 22 Neighboring gene large ribosomal subunit protein eL20-like Neighboring gene HMG-box transcription factor 1 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport. Walter DM, et al. J Biol Chem, 1998 Nov 6. PMID 9792665
    2. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar D, et al. J Cell Biol, 2002 Apr 29. PMID 11980916, Free PMC Article
    3. The binary interacting network of the conserved oligomeric Golgi tethering complex. Loh E, et al. J Biol Chem, 2004 Jun 4. PMID 15047703
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inter-Golgi cisterna vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    conserved oligomeric Golgi complex subunit 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398787.1 → NP_001385716.1  conserved oligomeric Golgi complex subunit 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K9P5
      Related
      ENSRNOP00000105012.1, ENSRNOT00000121267.1
      Conserved Domains (1) summary
      pfam10392
      Location:35 → 158
      COG5; Golgi transport complex subunit 5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      53969967..54267869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078121.2 → XP_038934049.1  conserved oligomeric Golgi complex subunit 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXD9
      Related
      ENSRNOP00000075077.3, ENSRNOT00000078953.3
      Conserved Domains (1) summary
      pfam10392
      Location:35 → 158
      COG5; Golgi transport complex subunit 5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools