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    Noxred1 NADP-dependent oxidoreductase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681924, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Noxred1provided by RGD
    Official Full Name
    NADP-dependent oxidoreductase domain containing 1provided by RGD
    Primary source
    RGD:1589353
    See related
    EnsemblRapid:ENSRNOG00000047312 AllianceGenome:RGD:1589353
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Orthologous to human NOXRED1 (NADP dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 57.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Noxred1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112593296..112619113, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106862350..106888113, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111243232..111271107, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein family member 8 Neighboring gene sterile alpha motif domain containing 15 Neighboring gene uncharacterized LOC134479236 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene activator of Hsp90 ATPase activity 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112593296..112619113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262690.1 → XP_063118760.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X2

    2. XM_006240402.5 → XP_006240464.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006240464.1

      UniProtKB/TrEMBL
      A6JE88, M0R8N7
      Related
      ENSRNOP00000111165.1, ENSRNOT00000158990.1
      Conserved Domains (1) summary
      cl21454
      Location:82 → 160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006240403.5 → XP_006240465.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006240465.1

      UniProtKB/TrEMBL
      A6JE88, M0R8N7
      Conserved Domains (1) summary
      cl21454
      Location:82 → 160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_039113335.2 → XP_038969263.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X2

    5. XM_006240401.5 → XP_006240463.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006240463.1

      UniProtKB/TrEMBL
      A6JE88, M0R8N7
      Conserved Domains (1) summary
      cl21454
      Location:82 → 160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_063262688.1 → XP_063118758.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X2

    7. XM_063262686.1 → XP_063118756.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JE88, M0R8N7

    8. XM_008764893.4 → XP_008763115.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008763115.1

      UniProtKB/TrEMBL
      A6JE88, M0R8N7
      Conserved Domains (1) summary
      cl21454
      Location:82 → 160
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    9. XM_063262689.1 → XP_063118759.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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