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    RPN5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851408, updated on 22-Aug-2024

    Summary

    Official Symbol
    RPN5
    Primary source
    FungiDB:YDL147W
    Locus tag
    YDL147W
    See related
    SGD:S000002306; AllianceGenome:SGD:S000002306; VEuPathDB:YDL147W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAS5
    Summary
    Involved in protein deneddylation. Located in proteasome storage granule. Part of COP9 signalosome and proteasome regulatory particle, lid subcomplex. Used to study cancer. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See RPN5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (190924..192261)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene autophagy protein ATG9 Neighboring gene snoRNA-binding rRNA-processing protein NOP14 Neighboring gene Ldb17p Neighboring gene coatomer subunit alpha

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome regulatory particle, lid subcomplex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome regulatory particle lid subunit RPN5
    NP_010134.1
    • Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      190924..192261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180207.1NP_010134.1  TPA: proteasome regulatory particle lid subunit RPN5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK1, Q12250
      UniProtKB/TrEMBL
      A6ZXI0, B5VFC1, C7GKZ8, C8Z6F5, G2WC14, N1P956
      Conserved Domains (1) summary
      COG5071
      Location:5445
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]