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    VAMP2 vesicle associated membrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 6844, updated on 28-Oct-2024

    Summary

    Official Symbol
    VAMP2provided by HGNC
    Official Full Name
    vesicle associated membrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12643
    See related
    Ensembl:ENSG00000220205 MIM:185881; AllianceGenome:HGNC:12643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYB2; VAMP-2; NEDHAHM
    Summary
    The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 159.3), ovary (RPKM 45.0) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VAMP2 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8159147..8162948, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8064587..8068400, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8062465..8066266, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8043207-8043885 Neighboring gene tRNA-Thr (anticodon AGT) 5-1 Neighboring gene period circadian regulator 1 Neighboring gene microRNA 6883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8053229-8053876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8163 Neighboring gene Sharpr-MPRA regulatory region 8148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8057595-8058375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11672 Neighboring gene uncharacterized LOC105371520 Neighboring gene transmembrane protein 107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11673 Neighboring gene small nucleolar RNA, C/D box 118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8079237-8079848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8079849-8080460

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11460

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin-1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-ion regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eosinophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in natural killer cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in neutrophil degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-sculpted glutamate transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in clathrin-sculpted monoamine transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuron projection terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein 2
    Names
    synaptobrevin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330125.1NP_001317054.1  vesicle-associated membrane protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC129492, BU625107
      Consensus CDS
      CCDS82064.1
      UniProtKB/TrEMBL
      F8WCA0, J3QRU4
      Related
      ENSP00000418572.1, ENST00000488857.5
      Conserved Domains (1) summary
      cd15870
      Location:3294
      R-SNARE_VAMP2; SNARE motif of VAMP2
    2. NM_014232.3NP_055047.2  vesicle-associated membrane protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055047.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC129492, AK021522, AK225777, BU625107
      Consensus CDS
      CCDS32561.1
      UniProtKB/Swiss-Prot
      P19065, P63027, Q9BUC2
      UniProtKB/TrEMBL
      J3QRU4
      Related
      ENSP00000314214.6, ENST00000316509.11
      Conserved Domains (1) summary
      cd15870
      Location:3092
      R-SNARE_VAMP2; SNARE motif of VAMP2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      8159147..8162948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      8064587..8068400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)