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    Arhgef4 Rho guanine nucleotide exchange factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301334, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgef4provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 4provided by RGD
    Primary source
    RGD:1586179
    See related
    EnsemblRapid:ENSRNOG00000014035 AllianceGenome:RGD:1586179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be active in cytosol. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 152.4), Thymus (RPKM 45.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef4 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44357716..44500959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36861800..37005079)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41160562..41305015)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thymosin beta-10-like Neighboring gene ribosomal protein lateral stalk subunit P1, pseudogene 1 Neighboring gene uncharacterized LOC120094663 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene uncharacterized LOC120094662 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function. Oh JY, et al. J Neurochem, 2018 Dec. PMID 30125942
    2. Activity of Arhgef4 is modulated through Staufen1 in neurons. Lee K, et al. Neurosci Lett, 2021 Jun 21. PMID 34022264
    3. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Kawasaki Y, et al. Oncogene, 2007 Dec 6. PMID 17599059
    4. Asef, a link between the tumor suppressor APC and G-protein signaling. Kawasaki Y, et al. Science, 2000 Aug 18. PMID 10947987
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of Arhgef4 is modulated through Staufen1 in neurons.
      Title: Activity of Arhgef4 is modulated through Staufen1 in neurons.
    2. our data reveal Arhgef4 functions as a negative regulator of synaptic localization of PSD-95 and synaptic transmission
      Title: Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 4
    Names
    Rho guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427642.1 → NP_001414571.1  rho guanine nucleotide exchange factor 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZKB4
      Related
      ENSRNOP00000018935.6, ENSRNOT00000018935.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44357716..44500959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084525.2 → XP_038940453.1  rho guanine nucleotide exchange factor 4 isoform X2

      Conserved Domains (3) summary
      cd11973
      Location:1141 → 1213
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:1250 → 1429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:1434 → 1573
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    2. XM_063266890.1 → XP_063122960.1  rho guanine nucleotide exchange factor 4 isoform X4

    3. XM_017596787.3 → XP_017452276.1  rho guanine nucleotide exchange factor 4 isoform X1

    4. XM_063266889.1 → XP_063122959.1  rho guanine nucleotide exchange factor 4 isoform X3

    5. XM_063266891.1 → XP_063122961.1  rho guanine nucleotide exchange factor 4 isoform X5

      Related
      ENSRNOP00000103915.1, ENSRNOT00000135503.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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