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    RGD1309362 similar to interferon-inducible GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307415, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RGD1309362provided by RGD
    Official Full Name
    similar to interferon-inducible GTPaseprovided by RGD
    Primary source
    RGD:1309362
    See related
    EnsemblRapid:ENSRNOG00000081104 AllianceGenome:RGD:1309362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ifgga1
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 51.0), Thymus (RPKM 38.5) and 8 other tissues See more
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    Genomic context

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    See RGD1309362 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (55943741..55969375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (55483059..55508714)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain-like Neighboring gene uncharacterized LOC102548951 Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene interferon-inducible GTPase 1-like Neighboring gene interferon-gamma-inducible GTPase 2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparative genomic analysis of eutherian interferon-γ-inducible GTPases. Premzl M. Funct Integr Genomics, 2012 Nov. PMID 22892676
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Clone Names

    • MGC116227

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    similar to interferon-inducible GTPase; uncharacterized protein LOC307415
    Names
    interferon-gamma-inducible GTPase Ifgga1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024884.2 → NP_001020055.1  similar to interferon-inducible GTPase

      See identical proteins and their annotated locations for NP_001020055.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      F7F0H6, Q4V797
      Related
      ENSRNOP00000102395.1, ENSRNOT00000126135.1
      Conserved Domains (2) summary
      cd04104
      Location:68 → 264
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:34 → 408
      IIGP; Interferon-inducible GTPase (IIGP)

    2. NM_001429145.1 → NP_001416074.1  similar to interferon-inducible GTPase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      Q4V797

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      55943741..55969375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277357.1 → XP_063133427.1  uncharacterized protein LOC307415 isoform X1

      Related
      ENSRNOP00000108942.1, ENSRNOT00000126462.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.