Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Magi3provided by RGD
Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 3provided by RGD
Primary source: RGD:621362
See related: EnsemblRapid:ENSRNOG00000019885 AllianceGenome:RGD:621362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slipr
Summary: Enables protein phosphatase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Predicted to be located in cell junction. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 243.5), Heart (RPKM 144.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (194206587..194405468, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (191514726..191717048, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (206499467..206699105, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-20b-5p contributes to the dysfunction of vascular smooth muscle cells by targeting MAGI3 in hypertension.
Title: MiR-20b-5p contributes to the dysfunction of vascular smooth muscle cells by targeting MAGI3 in hypertension.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Magi3 (e-PCR), detects polymorphism
- UniSTS:470541

AA859339 (e-PCR)
- UniSTS:261170

BE115259 (e-PCR)
- UniSTS:261464

RH124573 (e-PCR)
- UniSTS:161395

D2Wox34 (e-PCR)
- UniSTS:117962

BE098226 (e-PCR)
- UniSTS:245199

RH135900 (e-PCR)
- UniSTS:209898

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Names: MAGI-3; membrane-associated guanylate kinase inverted 3; membrane-associated guanylate kinase-related (MAGI-3); scaffolding protein SLIPR; scaffolding-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139084.3 → NP_620784.3 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9JK71

UniProtKB/TrEMBL

F1M7S0

Related

ENSRNOP00000026952.5, ENSRNOT00000026952.8

Conserved Domains (6) summary

smart00228
Location:729 → 812

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG5021
Location:211 → 373

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00201
Location:299 → 329

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1023 → 1101

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

PTZ00112
Location:1115 → 1405

PTZ00112; origin recognition complex 1 protein; Provisional

cl17190
Location:125 → 199

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

194206587..194405468 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101721.2 → XP_038957649.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9JK71

Conserved Domains (6) summary

smart00228
Location:711 → 794

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG5021
Location:211 → 373

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd00201
Location:299 → 329

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1005 → 1083

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

PTZ00112
Location:1097 → 1387

PTZ00112; origin recognition complex 1 protein; Provisional

cl17190
Location:125 → 199

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_008761367.4 → XP_008759589.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_008759589.1

UniProtKB/TrEMBL

A0A8I6AE46

Related

ENSRNOP00000090602.1, ENSRNOT00000098245.2

Conserved Domains (4) summary

smart00456
Location:297 → 329

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:729 → 812

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1023 → 1101

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl17190
Location:125 → 199

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...