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    ZNF177 zinc finger protein 177 [ Homo sapiens (human) ]

    Gene ID: 7730, updated on 19-Sep-2024

    Summary

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    Official Symbol
    ZNF177provided by HGNC
    Official Full Name
    zinc finger protein 177provided by HGNC
    Primary source
    HGNC:HGNC:12966
    See related
    Ensembl:ENSG00000188629 MIM:601276; AllianceGenome:HGNC:12966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIGX
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in blood microparticle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 5.2), ovary (RPKM 3.1) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF177 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9363013..9382617)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9489226..9508854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9473689..9493293)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF559-ZNF177 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10038 Neighboring gene zinc finger protein 559 Neighboring gene UBXN2A pseudogene 1 Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Landry JR, et al. Genomics, 2001 Aug. PMID 11549323
    2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Baban S, et al. Genomics, 1996 May 1. PMID 8661005
    3. NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. Wei X, et al. PLoS Pathog, 2019 Nov. PMID 31751430, Free PMC Article
    4. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article
    5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF559-ZNF177

    Readthrough gene: ZNF559-ZNF177, Included gene: ZNF559

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 177

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172651.2 → NP_001166122.1  zinc finger protein 177 isoform a

      See identical proteins and their annotated locations for NP_001166122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC011451
      Consensus CDS
      CCDS54214.1
      UniProtKB/Swiss-Prot
      B4DY57, E9PDG0, I3L0I4, Q13360, Q96ER2
      Related
      ENSP00000507083.1, ENST00000683217.1
      Conserved Domains (4) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:212 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:439 → 463
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001384658.1 → NP_001371587.1  zinc finger protein 177 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC011451
      Conserved Domains (4) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:87 → 282
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:126 → 146
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:279 → 303
      zf-H2C2_2; Zinc-finger double domain

    3. NM_003451.3 → NP_003442.2  zinc finger protein 177 isoform b

      See identical proteins and their annotated locations for NP_003442.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents additional exons in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a. A ZNF559-ZNF177 read-through variant, as represented by GeneID:100529215, also encodes isoform b.
      Source sequence(s)
      AC011451, BC012012, BX114567, U37263
      UniProtKB/Swiss-Prot
      Q13360
      Related
      ENSP00000341497.3, ENST00000343499.8
      Conserved Domains (4) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:87 → 282
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:126 → 146
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:279 → 303
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9363013..9382617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9489226..9508854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13360.4 GenPept UniProtKB/Swiss-Prot:Q13360

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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