PGA3 pepsinogen A3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGA3provided by HGNC
Official Full Name: pepsinogen A3provided by HGNC
Primary source: HGNC:HGNC:8885
See related: Ensembl:ENSG00000229859 MIM:169710; AllianceGenome:HGNC:8885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression: Restricted expression toward stomach (RPKM 21519.3) See more
Orthologs: all
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Genomic context

Location:: 11q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (61203515..61213098)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (61155047..61164627)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (60970987..60980570)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.
Title: Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.
Serum pepsinogen (PG), gastrin, and Helicobacter pylori (H. pylori) IgG antibodies have become indicators for "serological biopsy" of the gastric mucosa lesion.
Title: Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: an Observational Study.
Low Pepsinogen I is associated with precancerous gastric lesions.
Title: Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.
High serum Pepsinogen I level is associ9ated with the progression of gastric precancerous lesions.
Title: Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.
Significantly higher AUC was observed for the PGI/PGII ratio and is associated with atrophy and intestinal metaplasia.
Title: Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.
A significant negative correlation was found between the degree of corpus atrophy and the level of serum pepsinogen-I in atrophic gastritis patients with gastroesophageal reflux.
Title: Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study.
Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
Title: Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.
Title: Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer.
pepsinogens may have a role in esophageal squamous dysplasia
Title: Serum pepsinogens and risk of esophageal squamous dysplasia.
Higher levels of Pepsinogen I is associated with early gastric cancer
Title: Histologic and serum risk markers for noncardia early gastric cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R83655 (e-PCR)
- UniSTS:21261

GDB:197565 (e-PCR)
- UniSTS:155946

GDB:197855 (e-PCR)
- UniSTS:155970

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in multivesicular body lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pepsin A-3

Names: pepsinogen 3, group I (pepsinogen A); pepsinogen-3

NP_001073275.1

EC 3.4.23.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079807.4 → NP_001073275.1 pepsin A-3 preproprotein

See identical proteins and their annotated locations for NP_001073275.1

Status: REVIEWED

Source sequence(s)

AK225679, AK312941, AP000437

Consensus CDS

CCDS31574.1

UniProtKB/Swiss-Prot

B2R7D6, P0DJD8

UniProtKB/TrEMBL

B7ZW16

Related

ENSP00000322192.6, ENST00000325558.11

Conserved Domains (3) summary

cd05478
Location:66 → 386

pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals

pfam00026
Location:75 → 387

Asp; Eukaryotic aspartyl protease

pfam07966
Location:17 → 45

A1_Propeptide; A1 Propeptide