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    CDCP1 CUB domain containing protein 1 [ Homo sapiens (human) ]

    Gene ID: 64866, updated on 29-Oct-2024

    Summary

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    Official Symbol
    CDCP1provided by HGNC
    Official Full Name
    CUB domain containing protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24357
    See related
    Ensembl:ENSG00000163814 MIM:611735; AllianceGenome:HGNC:24357
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD318; TRASK; SIMA135
    Summary
    This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
    Expression
    Broad expression in esophagus (RPKM 12.2), skin (RPKM 11.1) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDCP1 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (45082277..45146482, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (45098021..45162916, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45123769..45187870, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene exosome component 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068175-45068676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45068677-45069176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45075939-45076588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45076589-45077236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14277 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14278 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene uncharacterized LOC124906233 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45165469-45165970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:45165971-45166470 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:45169788-45170032 Neighboring gene Sharpr-MPRA regulatory region 12576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:45207705-45208668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:45208669-45209632 Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:45240939-45242138 Neighboring gene uncharacterized LOC101928636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45256576-45257076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:45257077-45257577

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Oncogenic Ras/ERK signaling activates CDCP1 to promote tumor invasion and metastasis. Uekita T, et al. Mol Cancer Res, 2014 Oct. PMID 24939643
    2. Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. He Y, et al. J Biol Chem, 2010 Aug 20. PMID 20551327, Free PMC Article
    3. Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Spassov DS, et al. Mol Cell Biol, 2011 Feb. PMID 21189288, Free PMC Article
    4. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Liu H, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21220330, Free PMC Article
    5. The structural features of Trask that mediate its anti-adhesive functions. Spassov DS, et al. PLoS One, 2011 Apr 29. PMID 21559459, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation.
      Title: The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation.
    2. Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
      Title: Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
    3. Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
      Title: Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
    4. CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma.
      Title: CDCP1 (CUB domain containing protein 1) is a potential urine-based biomarker in the diagnosis of low-grade urothelial carcinoma.
    5. CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
      Title: CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.
    6. Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia.
      Title: Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia.
    7. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer.
      Title: CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer.
    8. SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
      Title: SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
    9. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
      Title: Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
    10. Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer.
      Title: Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUB domain-containing protein 1
    Names
    membrane glycoprotein gp140
    subtractive immunization M plus HEp3-associated 135 kDa protein
    transmembrane and associated with src kinases

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022842.5 → NP_073753.3  CUB domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_073753.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY026461, AY167484
      Consensus CDS
      CCDS2727.1
      UniProtKB/Swiss-Prot
      Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H5V8, Q9H676, Q9H8C2
      Related
      ENSP00000296129.1, ENST00000296129.6
      Conserved Domains (1) summary
      cl00049
      Location:225 → 297
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. NM_178181.3 → NP_835488.1  CUB domain-containing protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_835488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AY358779, BC021099
      Consensus CDS
      CCDS46812.1
      UniProtKB/Swiss-Prot
      Q9H5V8
      Related
      ENSP00000399342.2, ENST00000425231.2
      Conserved Domains (1) summary
      cl00049
      Location:225 → 297
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      45082277..45146482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453718.2 → XP_024309486.1  CUB domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      cl00049
      Location:159 → 231
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. XM_011534024.2 → XP_011532326.1  CUB domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cl00049
      Location:224 → 296
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    3. XM_017007070.2 → XP_016862559.1  CUB domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0Y0BS51, A0A172Q398

    4. XM_047448759.1 → XP_047304715.1  CUB domain-containing protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      45098021..45162916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347604.1 → XP_054203579.1  CUB domain-containing protein 1 isoform X3

    2. XM_054347602.1 → XP_054203577.1  CUB domain-containing protein 1 isoform X1

    3. XM_054347603.1 → XP_054203578.1  CUB domain-containing protein 1 isoform X2

    4. XM_054347605.1 → XP_054203580.1  CUB domain-containing protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H5V8.3 GenPept UniProtKB/Swiss-Prot:Q9H5V8

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