LTE1 mitotic regulator LTE1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LTE1
Official Full Name: mitotic regulator LTE1
Primary source: SGD:S000000022
Locus tag: YAL024C
See related: AllianceGenome:SGD:S000000022; FungiDB:YAL024C; VEuPathDB:YAL024C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MSI2
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in asymmetric protein localization to new mitotic spindle pole body; positive regulation of exit from mitosis; and vesicle-mediated transport. Located in cellular bud. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7; hypertension; immunodeficiency 64; and platelet-type bleeding disorder 18. Orthologous to several human genes including RASGRP1 (RAS guanyl releasing protein 1); RASGRP2 (RAS guanyl releasing protein 2); and RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LTE1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (101565..105872, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that bud-localized MEN regulator Lte1 prevents Kin4 that escapes into the bud from associating with SPBs in the daughter cell.
Title: Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.
Data suggest that Lte1 promotes mitotic exit by inhibiting Kin4 activity at the daughter spindle pole body.
Title: The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.
Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae
Title: Phosphorylation of Lte1 by Cdk prevents polarized growth during mitotic arrest in S. cerevisiae.
Lte1 can determine the subcellular localization of Bfa1 at spindle pole bodies (SPB) by promoting the loss of Bfa1 from the maternal SPB.
Title: Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1.
In lteDelta cells Brn1 release was delayed, even at temperatures that do not impair mitotic exit.
Title: Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
analysis of a link between the mitotic regulator, Lte1p, and protein processing and trafficking in the secretory/endosomal system
Title: A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway.
Our findings suggest that Cla4-dependent phosphorylation promotes the initial association of Lte1 with Ras at the bud cortex and that Ras is required to stabilize phosphorylated forms of Lte1 at the bud cortex.
Title: Ras and the Rho effector Cla4 collaborate to target and anchor Lte1 at the bud cortex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric protein localization to new mitotic spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitotic regulator LTE1

NP_009378.1

Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

101565..105872 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178169.1 → NP_009378.1 TPA: mitotic regulator LTE1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009378.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPJ4, P07866

UniProtKB/TrEMBL

B3LUV8, B5VDJ7, C8Z3K3, N1P7J8

Conserved Domains (2) summary

smart00229
Location:28 → 156

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:1190 → 1434

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...