U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AST1 Ast1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852209, updated on 29-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    AST1
    Gene description
    Ast1p
    Primary source
    FungiDB:YBL069W
    Locus tag
    YBL069W
    See related
    SGD:S000000165; AllianceGenome:SGD:S000000165; VEuPathDB:YBL069W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable oxidoreductase activity. Involved in protein targeting to membrane and protein transport into membrane raft. Located in several cellular components, including Golgi apparatus; late endosome; and membrane raft. Human ortholog(s) of this gene implicated in optic atrophy 10. Orthologous to human RTN4IP1 (reticulon 4 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AST1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (90741..92030)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kti11p Neighboring gene uncharacterized protein Neighboring gene ribose phosphate diphosphokinase subunit PRS4 Neighboring gene ubiquitin-specific protease UBP13

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors. Vanmarcke G, et al. PLoS Genet, 2021 Oct. PMID 34624020, Free PMC Article
    2. Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. Bagnat M, et al. Mol Biol Cell, 2001 Dec. PMID 11739806, Free PMC Article
    3. Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. Chang A, et al. J Cell Biol, 1995 Jan. PMID 7822420, Free PMC Article
    4. Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily. Riveros-Rosas H, et al. Eur J Biochem, 2003 Aug. PMID 12899689
    5. Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae. He C, et al. J Proteome Res, 2018 Jul 6. PMID 29897761

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport into membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport into membrane raft IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ast1p
    NP_009484.2
    • Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      90741..92030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178309.1 → NP_009484.2  TPA: Ast1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009484.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPT2, P35183, P89492
      UniProtKB/TrEMBL
      A0A6A5Q1P7, A6ZKN1, B3LNK3, B5VDR8, C7GN98, C8Z3S6, G2W8U1, N1P8R9
      Conserved Domains (1) summary
      cd08247
      Location:50 → 426
      AST1_like; AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35183.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools