U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AKL1 serine/threonine protein kinase AKL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852351, updated on 7-Jul-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    AKL1
    Gene description
    serine/threonine protein kinase AKL1
    Primary source
    FungiDB:YBR059C
    Locus tag
    YBR059C
    See related
    SGD:S000000263; AllianceGenome:SGD:S000000263; VEuPathDB:YBR059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in negative regulation of clathrin-dependent endocytosis; peptidyl-threonine phosphorylation; and protein autophosphorylation. Located in several cellular components, including cell periphery; cellular bud neck; and prospore membrane. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AKL1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (356861..360187, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene Tsc3p Neighboring gene origin recognition complex subunit 2 Neighboring gene tRNA methyltransferase TRM7

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [A screen for genes involved in adriamycin resistance in Saccharomyces cerevisiae]. Takahashi T. Yakugaku Zasshi, 2013. PMID 23449420
    2. TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae. Roelants FM, et al. Mol Cell Biol, 2017 Apr 1. PMID 28069741, Free PMC Article
    3. The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Henry KR, et al. Curr Biol, 2003 Sep 2. PMID 12956961
    4. High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast. Demir AB, et al. PLoS One, 2015. PMID 26690737, Free PMC Article
    5. Manipulating cell flocculation-associated protein kinases in Saccharomyces cerevisiae enables improved stress tolerance and efficient cellulosic ethanol production. Ye PL, et al. Bioresour Technol, 2022 Mar. PMID 35134528

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORC2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.
      Title: Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine protein kinase AKL1
    NP_009615.1
    • Ser/Thr protein kinase; phosphorylates Pan1p, Sla1p and Ent1p to negatively regulate endocytosis in response to membrane stress; regulates actin cytoskeleton organization and clathrin-dependent endocytosis; phosphorylated and inhibited by upstream kinase, Fpk1p; member, along with Ark1p and Prk1p, of the Ark kinase family

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      356861..360187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178407.1 → NP_009615.1  TPA: serine/threonine protein kinase AKL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009615.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ59, P38080
      UniProtKB/TrEMBL
      A0A8H4F6D8, A6ZL04, C7GQH5, D3UEF7, N1PAR9
      Conserved Domains (1) summary
      cd14037
      Location:31 → 322
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38080.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools