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    SSE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852467, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SSE2
    Primary source
    SGD:S000000373
    Locus tag
    YBR169C
    See related
    AllianceGenome:SGD:S000000373; FungiDB:YBR169C; VEuPathDB:YBR169C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenyl-nucleotide exchange factor activity. Involved in proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein refolding. Located in cytoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to several human genes including HSPA4 (heat shock protein family A (Hsp70) member 4) and HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (573915..575996, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP protein subunit POP7 Neighboring gene Pex32p Neighboring gene nuclear protein localization protein 4 Neighboring gene Sec63 complex subunit SEC66

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae. Kaimal JM, et al. Mol Cell Biol, 2017 Jun 1. PMID 28289075, Free PMC Article
    2. The control of spindle length by Hsp70 and Hsp110 molecular chaperones. Makhnevych T, et al. FEBS Lett, 2013 Apr 17. PMID 23434584
    3. Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein. Polier S, et al. J Mol Biol, 2010 Sep 3. PMID 20624400
    4. Isolation and characterization of SSE1 and SSE2, new members of the yeast HSP70 multigene family. Mukai H, et al. Gene, 1993 Sep 30. PMID 8406043
    5. Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Ghosh A, et al. Cell Mol Life Sci, 2019 Apr. PMID 30683983, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenyl-nucleotide exchange factor SSE2
    NP_009728.1
    • Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      573915..575996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178517.1 → NP_009728.1  TPA: adenyl-nucleotide exchange factor SSE2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQG5, P32590
      UniProtKB/TrEMBL
      A6ZLB2, D3UER4, N1PAU3
      Conserved Domains (1) summary
      pfam00012
      Location:4 → 644
      HSP70; Hsp70 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32590.3

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