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    KTR3 mannosyltransferase KTR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852504, updated on 29-Jun-2024

    Summary

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    Gene symbol
    KTR3
    Gene description
    mannosyltransferase KTR3
    Primary source
    FungiDB:YBR205W
    Locus tag
    YBR205W
    See related
    SGD:S000000409; AllianceGenome:SGD:S000000409; VEuPathDB:YBR205W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mannosyltransferase activity. Involved in N-glycan processing and protein O-linked glycosylation. Located in fungal-type vacuole membrane and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KTR3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (633622..634836)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Cos111p Neighboring gene triacylglycerol lipase Neighboring gene Fth1p Neighboring gene bifunctional urea carboxylase/allophanate hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae. Tanabe Y, et al. J Gen Appl Microbiol, 2019 Sep 14. PMID 30700649
    2. Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. Bue CA, et al. J Biol Chem, 2009 Sep 4. PMID 19574229, Free PMC Article
    3. The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. Lussier M, et al. J Biol Chem, 1997 Jun 13. PMID 9182588
    4. Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family. Lussier M, et al. J Biol Chem, 1996 May 3. PMID 8631921
    5. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER. Noda Y, et al. Biol Open, 2014 Mar 15. PMID 24585773, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mannosyltransferase KTR3
    NP_009764.3
    • Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      633622..634836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178553.3 → NP_009764.3  TPA: mannosyltransferase KTR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009764.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK3, E9P931, P38130
      UniProtKB/TrEMBL
      A0A6A5Q0A5, A6ZLE7, B3LMV3, B5VEF7, C7GKG8, D3UEV2, G2W9L0
      Conserved Domains (1) summary
      COG5020
      Location:1 → 404
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38130.1

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