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    TSC10 3-dehydrosphinganine reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852568, updated on 7-Jul-2024

    Summary

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    Gene symbol
    TSC10
    Gene description
    3-dehydrosphinganine reductase
    Primary source
    FungiDB:YBR265W
    Locus tag
    YBR265W
    See related
    SGD:S000000469; AllianceGenome:SGD:S000000469; VEuPathDB:YBR265W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-dehydrosphinganine reductase activity. Involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Located in lipid droplet. Used to study erythrokeratodermia variabilis et progressiva 4. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TSC10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (738582..739544)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene glycine hydroxymethyltransferase SHM1 Neighboring gene Rab family GTPase YPT10 Neighboring gene Rei1p Neighboring gene Slm6p Neighboring gene mitochondrial 54S ribosomal protein YmL37

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. Shen Y, et al. Science, 2017 Mar 10. PMID 28280153, Free PMC Article
    2. Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals. Gupta SD, et al. J Lipid Res, 2009 Aug. PMID 19141869, Free PMC Article
    3. Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma. Boyden LM, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575652, Free PMC Article
    4. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. Kihara A, et al. J Biol Chem, 2004 Nov 19. PMID 15328338
    5. CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. Healey KR, et al. Mol Microbiol, 2012 Oct. PMID 22909030, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-dehydrosphinganine reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-dehydrosphinganine reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-dehydrosphinganine reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-keto-sphinganine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3-keto-sphinganine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3-keto-sphinganine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 

    General protein information

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    Preferred Names
    3-dehydrosphinganine reductase
    NP_009824.2
    • 3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; mutations in human homolog KDSR cause recessive progressive symmetric erythrokeratoderma

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      738582..739544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178613.2 → NP_009824.2  TPA: 3-dehydrosphinganine reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009824.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQR2, P38342
      UniProtKB/TrEMBL
      A0A8H4BVF6, A6ZLK5, B3LMP6, C7GMW5, D3UF13, G2W9S0, N1P8U4
      Conserved Domains (1) summary
      cd08939
      Location:7 → 263
      KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38342.2

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