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    PRD1 metalloendopeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850301, updated on 17-May-2024

    Summary

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    Gene symbol
    PRD1
    Gene description
    metalloendopeptidase
    Primary source
    FungiDB:YCL057W
    Locus tag
    YCL057W
    See related
    SGD:S000000562; AllianceGenome:SGD:S000000562; VEuPathDB:YCL057W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables metalloendopeptidase activity. Involved in proteolysis. Located in Golgi apparatus; fungal-type vacuole; and mitochondrial intermembrane space. Orthologous to several human genes including THOP1 (thimet oligopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRD1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (24768..26906)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fyv5p Neighboring gene Adf1p Neighboring gene Mic10p Neighboring gene Pex34p Neighboring gene Kar4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Landscape of submitochondrial protein distribution. Vögtle FN, et al. Nat Commun, 2017 Aug 18. PMID 28819139, Free PMC Article
    2. Proteinase yscD (oligopeptidase yscD). Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15). Büchler M, et al. Eur J Biochem, 1994 Jan 15. PMID 8307027
    3. Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Hrycyna CA, et al. Biochemistry, 1993 Oct 26. PMID 8218194
    4. Proteinase yscD. Purification and characterization of a new yeast peptidase. Achstetter T, et al. J Biol Chem, 1985 Apr 25. PMID 3886641
    5. MIP1, a new yeast gene homologous to the rat mitochondrial intermediate peptidase gene, is required for oxidative metabolism in Saccharomyces cerevisiae. Isaya G, et al. Mol Cell Biol, 1994 Aug. PMID 8035833, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    metalloendopeptidase
    NP_009874.1
    • Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      24768..26906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178701.1 → NP_009874.1  TPA: metalloendopeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW0, E9P942, P25375
      UniProtKB/TrEMBL
      A0A8H4BTH7, A6ZTD8, B3LU28
      Conserved Domains (1) summary
      cd06455
      Location:54 → 708
      M3A_TOP; Peptidase M3 thimet oligopeptidase (TOP), also includes neurolysin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25375.1

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