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    GEX1 glutathione exchanger [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850289, updated on 17-May-2024

    Summary

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    Gene symbol
    GEX1
    Gene description
    glutathione exchanger
    Primary source
    FungiDB:YCL073C
    Locus tag
    YCL073C
    See related
    SGD:S000000575; AllianceGenome:SGD:S000000575; VEuPathDB:YCL073C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables solute:proton antiporter activity. Involved in glutathione transmembrane transport. Located in plasma membrane and vacuolar membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GEX1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (6479..8326, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene basic amino acid transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subtelomeric duplications in Saccharomyces cerevisiae chromosomes III and XI: topology, arrangements, corrections of sequence and strain-specific polymorphism. Gromadka R, et al. Yeast, 1996 May. PMID 8771713
    2. Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration. Simpkins JA, et al. Biol Open, 2016 Jun 15. PMID 27142334, Free PMC Article
    3. Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Dhaoui M, et al. Mol Biol Cell, 2011 Jun 15. PMID 21490148, Free PMC Article
    4. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Hu B, et al. Mol Microbiol, 2005 Mar. PMID 15752197
    5. Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1). Millson S, et al. Cell Stress Chaperones, 2014 Sep. PMID 24452458, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables siderophore-iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione exchanger
    NP_009863.2
    • Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      6479..8326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178711.1 → NP_009863.2  TPA: glutathione exchanger [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009863.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQU9, P25596, P25597, P25599, P87002, Q8NIN5
      UniProtKB/TrEMBL
      A0A8H4BTB1, B3LU17
      Conserved Domains (1) summary
      cd17322
      Location:59 → 571
      MFS_ARN_like; Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25596.4

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