RVS161 amphiphysin-like protein RVS161 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RVS161
Official Full Name: amphiphysin-like protein RVS161
Primary source: SGD:S000000602
Locus tag: YCR009C
See related: AllianceGenome:SGD:S000000602; FungiDB:YCR009C; VEuPathDB:YCR009C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: END6; FUS7; SPE161
Summary: Enables cytoskeletal protein binding activity. Contributes to lipid binding activity. Involved in several processes, including actin cortical patch localization; lipid tube assembly; and plasma membrane tubulation. Located in actin cortical patch; mating projection; and membrane raft. Part of Rvs161p-Rvs167p complex. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

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Cells lacking Rvs161 are inviable and altering sphingolipid metabolism when starved for glucose.
Title: Altering sphingolipid metabolism in Saccharomyces cerevisiae cells lacking the amphiphysin ortholog Rvs161 reinitiates sugar transporter endocytosis.
synthetic lethal interaction between loss of CDC55 and gene deletions lethal with rvs161, all of which function in endocytosis.
Title: Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis.
SUR4 does not remediate the steady-state actin cytoskeletal defects of rvs167 or rvs161 cells
Title: Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p.
RVS161 and RVS167 have an identical set of 49 synthetic lethal interactions, revealing functions for the Rvs proteins in cell polarity, cell wall synthesis, and vesicle trafficking as well as a shared role in mating.
Title: Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to lipid binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to lipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cortical patch localization	IEA Inferred from Electronic Annotation more info
involved_in actin cortical patch localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid tube assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rvs161p-Rvs167p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rvs161p-Rvs167p complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in actin cortical patch	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in mating projection	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
is_active_in mating projection tip	IBA Inferred from Biological aspect of Ancestor more info
is_active_in medial cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed

NP_009935.1

Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress

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