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    SNU23 U4/U6-U5 snRNP complex subunit SNU23 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SNU23
    Official Full Name
    U4/U6-U5 snRNP complex subunit SNU23
    Primary source
    SGD:S000002256
    Locus tag
    YDL098C
    See related
    AllianceGenome:SGD:S000002256; FungiDB:YDL098C; VEuPathDB:YDL098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Part of U4/U6 x U5 tri-snRNP complex. Orthologous to human ZMAT2 (zinc finger matrin-type 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SNU23 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (284581..285165, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene guanine nucleotide exchange factor GET3 Neighboring gene Bug1p Neighboring gene proteasome regulatory particle lid subunit RPN6 Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing. Ohkura N, et al. J Biol Chem, 2002 Jan 4. PMID 11673470
    2. Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor. Ulrich AK, et al. BMC Evol Biol, 2017 Mar 24. PMID 28335716, Free PMC Article
    3. Structure of a pre-catalytic spliceosome. Plaschka C, et al. Nature, 2017 Jun 29. PMID 28530653, Free PMC Article
    4. Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Häcker I, et al. Nat Struct Mol Biol, 2008 Nov. PMID 18953335
    5. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Stevens SW, et al. Proc Natl Acad Sci U S A, 1999 Jun 22. PMID 10377396, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit SNU23
    NP_010185.1
    • Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      284581..285165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180157.1 → NP_010185.1  TPA: U4/U6-U5 snRNP complex subunit SNU23 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRQ2, Q12368
      UniProtKB/TrEMBL
      A6ZXN1, B3LGZ1, C7GJL8, C8Z6K6, G2WC66, N1PA94
      Conserved Domains (1) summary
      pfam12874
      Location:80 → 104
      zf-met; Zinc-finger of C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12368.1

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