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    RPC11 DNA-directed RNA polymerase III core subunit RPC11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851615, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPC11
    Gene description
    DNA-directed RNA polymerase III core subunit RPC11
    Primary source
    FungiDB:YDR045C
    Locus tag
    YDR045C
    See related
    SGD:S000002452; AllianceGenome:SGD:S000002452; VEuPathDB:YDR045C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and termination of RNA polymerase III transcription. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPC11 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (547978..548310, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene transcriptional regulator NRG1 Neighboring gene coproporphyrinogen oxidase Neighboring gene amino acid transporter BAP3 Neighboring gene uroporphyrinogen decarboxylase HEM12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination. Chédin S, et al. Genes Dev, 1998 Dec 15. PMID 9869639, Free PMC Article
    2. Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element. Arimbasseri AG, et al. Mol Cell, 2015 Jun 18. PMID 25959395, Free PMC Article
    3. Distinguishing core and holoenzyme mechanisms of transcription termination by RNA polymerase III. Arimbasseri AG, et al. Mol Cell Biol, 2013 Apr. PMID 23401852, Free PMC Article
    4. The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening. Kassavetis GA, et al. J Biol Chem, 2010 Jan 22. PMID 19940126, Free PMC Article
    5. A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation. Landrieux E, et al. EMBO J, 2006 Jan 11. PMID 16362040, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Date indicate that RNA Polymerase III (RNAP III) subunits C53, C37, and C11 are required for pre-termination complex (PTC) formation.
      Title: Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase III transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase III transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III core subunit RPC11
    NP_010330.1
    • RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      547978..548310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180353.1 → NP_010330.1  TPA: DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010330.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS33, Q04307, Q2VQW5
      UniProtKB/TrEMBL
      A0A6L0Y5S7, A6ZY12, B3LGM2, C7GTA4, C8Z4W5, G2WAF1, N1P824
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04307.1

    Gene LinkOut

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