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    TGL2 triglyceride lipase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851628, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TGL2
    Official Full Name
    triglyceride lipase
    Primary source
    SGD:S000002465
    Locus tag
    YDR058C
    See related
    AllianceGenome:SGD:S000002465; FungiDB:YDR058C; VEuPathDB:YDR058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables triacylglycerol lipase activity. Involved in triglyceride catabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TGL2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (567723..568703, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Emc10p Neighboring gene Yos9p Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae TGL2 gene encodes a protein with lipolytic activity and can complement an Escherichia coli diacylglycerol kinase disruptant. Van Heusden GP, et al. Yeast, 1998 Feb. PMID 9544243
    2. The TGL2 gene of Saccharomyces cerevisiae encodes an active acylglycerol lipase located in the mitochondria. Ham HJ, et al. J Biol Chem, 2010 Jan 29. PMID 19959834, Free PMC Article
    3. Label-free measurement of the yeast short chain TAG lipase activity by ESI-MS after one-step esterification. Ham HJ, et al. J Lipid Res, 2017 Mar. PMID 28119444, Free PMC Article
    4. The mitochondrial intermembrane space-facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism. Odendall F, et al. Mol Biol Cell, 2019 Oct 1. PMID 31483742, Free PMC Article
    5. Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Qin T, et al. Nucleic Acids Res, 2014 Oct. PMID 25063300, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that mitochondrial protein MCP2 (MCP2) has a negative genetic interaction with the gene triglyceride lipase TGL2 (TGL2) encoding a neutral lipid hydrolase.
      Title: The mitochondrial intermembrane space-facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism.
    2. mitochondrial Tgl2p-dependent lipolysis is crucial for the survival of cells under antimitotic drug treatment
      Title: The TGL2 gene of Saccharomyces cerevisiae encodes an active acylglycerol lipase located in the mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triglyceride lipase
    NP_010343.1
    • Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      567723..568703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180366.1 → NP_010343.1  TPA: triglyceride lipase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS44, E9P8S6, P54857
      UniProtKB/TrEMBL
      A6ZY23, B3LGL1, B5VFV8, C7GT93, C8Z4X7, N1P4L1
      Conserved Domains (1) summary
      COG1075
      Location:4 → 323
      EstA; Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54857.1

    Gene LinkOut

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