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    VMA3 H(+)-transporting V0 sector ATPase subunit c [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856686, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VMA3
    Official Full Name
    H(+)-transporting V0 sector ATPase subunit c
    Primary source
    SGD:S000000753
    Locus tag
    YEL027W
    See related
    AllianceGenome:SGD:S000000753; FungiDB:YEL027W; VEuPathDB:YEL027W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS7; CUP5; GEF2
    Summary
    Predicted to enable proton transmembrane transporter activity. Involved in several processes, including cellular cation homeostasis; protein targeting to vacuole; and vacuole organization. Is integral component of membrane. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VMA3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (100769..101251)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Met Neighboring gene RNA binding protein SNU13 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase. Bockelmann S, et al. J Biol Chem, 2010 Dec 3. PMID 20884613, Free PMC Article
    2. Binding assays of inhibitors towards selected V-ATPase domains. Fernandes F, et al. Biochim Biophys Acta, 2006 Nov. PMID 16996024
    3. Iejimalides show anti-osteoclast activity via V-ATPase inhibition. Kazami S, et al. Biosci Biotechnol Biochem, 2006 Jun. PMID 16794315
    4. Proteolipid of vacuolar H(+)-ATPase of Plasmodium falciparum: cDNA cloning, gene organization and complementation of a yeast null mutant. Yatsushiro S, et al. Biochim Biophys Acta, 2005 Nov 30. PMID 16293223
    5. Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis. Gupta SS, et al. J Biol Chem, 2003 Aug 1. PMID 12754197

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, we have proposed a working model to describe how Vma3p protects cells against apoptosis through the regulation of HXK2 expression.
      Title: Vma3p protects cells from programmed cell death through the regulation of Hxk2p expression.
    2. These findings suggest a role for vacuolar proton translocation ATPase in the regulation of the cell wall stress response and the prevention of endogenous oxidative stress in response to ethanol.
      Title: Vacuolar H+-ATPase Protects Saccharomyces cerevisiae Cells against Ethanol-Induced Oxidative and Cell Wall Stresses.
    3. Peptides corresponding to 2nd & 4th transmembrane domains (TM2 & TM4) of proteolipid subunit c (Vma3p) & of putative 7th transmembrane domain (TM7) of subunit a (Vph1p) are predominantly, alpha-helical in membranes of dioleoyl phosphatidylcholine.
      Title: Incorporation of transmembrane peptides from the vacuolar H(+)-ATPase in phospholipid membranes: spin-label electron paramagnetic resonance and polarized infrared spectroscopy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-transporting V0 sector ATPase subunit c
    NP_010887.3
    • Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      100769..101251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178842.3 → NP_010887.3  TPA: H(+)-transporting V0 sector ATPase subunit c [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010887.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLM1, P25515
      UniProtKB/TrEMBL
      A6ZQS1, B3LRY8, C7GX15, C8Z6X0, G2WCK4, N1P3T2
      Conserved Domains (2) summary
      TIGR01100
      Location:11 → 116
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:84 → 151
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25515.1

    Gene LinkOut

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