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    SBH1 Arf family guanine nucleotide exchange factor SBH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856821, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SBH1
    Official Full Name
    Arf family guanine nucleotide exchange factor SBH1
    Primary source
    SGD:S000002128
    Locus tag
    YER087C-B
    See related
    AllianceGenome:SGD:S000002128; FungiDB:YER087C-B; VEuPathDB:YER087C-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEB1; YER087C-A
    Summary
    Enables guanyl-nucleotide exchange factor activity and protein transmembrane transporter activity. Contributes to protein-transporting ATPase activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum membrane. Part of Sec61 translocon complex. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SBH1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (332582..332830, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene threonine ammonia-lyase ILV1 Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Dot6p Neighboring gene type 2C protein phosphatase PTC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inter-species complementation of the translocon beta subunit requires only its transmembrane domain. Leroux A, et al. PLoS One, 2008. PMID 19057642, Free PMC Article
    2. The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor. Helmers J, et al. J Biol Chem, 2003 Jun 27. PMID 12750387
    3. Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation. Barbieri G, et al. J Biol Chem, 2023 Mar. PMID 36639027, Free PMC Article
    4. The N-terminus of Sec61p plays key roles in ER protein import and ERAD. Elia F, et al. PLoS One, 2019. PMID 31017954, Free PMC Article
    5. Posttranslational protein translocation across the membrane of the endoplasmic reticulum. Rapoport TA, et al. Biol Chem, 1999 Oct. PMID 10595576

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sec61 channel subunit Sbh1/Sec61beta promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
      Title: Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
    2. Data suggest that Bat3 either modulates the Sec61beta/TRC40 pathway in higher eukaryotes or provides an alternative fate for newly synthesised tail-anchored proteins.
      Title: Bat3 promotes the membrane integration of tail-anchored proteins.
    3. Sbh1p co-precipitates with the ER transmembrane protein Rtn1p. Sbh1p-Rtn1p complexes do not appear to contain Sss1p and Sec61p.
      Title: The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.
    4. Ost3p and Ost6p are similar, but do not exist in the same oligosaccharyltransferase complex: Ost3p interacts with Sbh1p, while Ost6p interacts with Sbh2p.
      Title: Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to protein-transporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec61 translocon complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sec61 translocon complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arf family guanine nucleotide exchange factor SBH1
    NP_011011.3
    • Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      332582..332830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180032.3 → NP_011011.3  TPA: Arf family guanine nucleotide exchange factor SBH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011011.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ4, P52870
      UniProtKB/TrEMBL
      A6ZR43, B3LRK5, C7GRS0, C8Z7A2, G2WCX8, N1P582
      Conserved Domains (1) summary
      pfam03911
      Location:38 → 74
      Sec61_beta; Sec61beta family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52870.1

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