HOS2 histone deacetylase HOS2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: HOS2
Gene description: histone deacetylase HOS2
Primary source: FungiDB:YGL194C
Locus tag: YGL194C
See related: SGD:S000003162; AllianceGenome:SGD:S000003162; VEuPathDB:YGL194C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RTL1
Summary: Enables NAD-dependent histone deacetylase activity and NAD-independent histone deacetylase activity. Involved in several processes, including histone deacetylation; negative regulation of meiotic nuclear division; and positive regulation of stress-activated MAPK cascade. Located in nuclear periphery. Part of Set3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HOS2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (140368..141726, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results uncover an unexpected role for histone deacetylases (Rpd3 and Hos2) in promoting Spt6 interaction with elongating Pol II.
Title: Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly.
observed the formation of a reversible cytosolic "stationary-phase granule" by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability.
Title: The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells.
both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes
Title: Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae.
the Hos2p/Set3p complex (SET3C) is a novel component critical for cell survival in response to secretory stress.
Title: Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway.
Two histone deacetylases, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1.
Title: Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes.
Hos2 and Set3 function at tRNA genes to promote Ty1 integration
Title: Hos2 and Set3 promote integration of Ty1 retrotransposons at tRNA genes in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD-independent histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rpd3L-Expanded complex	HDA more info	PubMed
part_of Rpd3L-Expanded complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: histone deacetylase HOS2

NP_011321.1

EC 3.5.1.98

Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

140368..141726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181059.1 → NP_011321.1 TPA: histone deacetylase HOS2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011321.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTW0, P53096

UniProtKB/TrEMBL

A0A6L0Z947, A6ZTZ5, B3LHP2, C7GX01, G2WDR3, N1P6D2

Conserved Domains (1) summary

cd11598
Location:28 → 338

HDAC_Hos2; Class I histone deacetylases including ScHos2 and SpPhd1