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    ADE57 bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852617, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADE57
    Official Full Name
    bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
    Primary source
    SGD:S000003203
    Locus tag
    YGL234W
    See related
    AllianceGenome:SGD:S000003203; FungiDB:YGL234W; VEuPathDB:YGL234W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Predicted to be involved in adenine biosynthetic process and purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ADE57 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (56482..58890)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription activator HAP2 Neighboring gene tRNA modification protein MTO1 Neighboring gene uncharacterized protein Neighboring gene Rab GTPase-binding exocyst subunit SEC15 Neighboring gene putative tRNA acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UGA mutations and UGA suppressors in yeast. Hawthorne DC. Biochimie, 1976. PMID 782552
    2. [Glycine amide ribonucleotide synthetase (EC 6.3.4.13)--is aminoimidazole ribonucleotide synthetase (EC 6.3.3.1) from Saccharomyces cerevisiae]. Tret'iakov OIu, et al. Biokhimiia, 1995 Dec. PMID 8600995
    3. The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides. Henikoff S. J Mol Biol, 1986 Aug 20. PMID 3097325
    4. Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Daignan-Fornier B, et al. Proc Natl Acad Sci U S A, 1992 Aug 1. PMID 1495962, Free PMC Article
    5. The transcriptional activators BAS1, BAS2, and ABF1 bind positive regulatory sites as the critical elements for adenine regulation of ADE5,7. Rolfes RJ, et al. J Biol Chem, 1997 May 16. PMID 9148957

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
    NP_011280.1
    • Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) ['Ade5'] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) ['Ade7'] activities

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      56482..58890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181100.1 → NP_011280.1  TPA: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA0, E9P907, P07244
      UniProtKB/TrEMBL
      A6ZTV6, B3LHS7, C7GNY1, C8Z821, G2WDM5, N1P3F9
      Conserved Domains (2) summary
      TIGR00877
      Location:2 → 441
      purD; phosphoribosylamine--glycine ligase
      TIGR00878
      Location:450 → 786
      purM; phosphoribosylaminoimidazole synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07244.1

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