UGA1 4-aminobutyrate transaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: UGA1
Gene description: 4-aminobutyrate transaminase
Primary source: FungiDB:YGR019W
Locus tag: YGR019W
See related: SGD:S000003251; AllianceGenome:SGD:S000003251; VEuPathDB:YGR019W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 4-aminobutyrate transaminase activity. Involved in gamma-aminobutyric acid catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UGA1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (525229..526644)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtGABA-T is functionally interchangeable with ScGABA-TKG for GABA growth, thermotolerance and limiting production of ROS, regardless of location in mitochondria or cytosol of yeast cells, but AtGABA-T is about half as efficient in doing so as ScGABA-TKG.
Title: GABA transaminases from Saccharomyces cerevisiae and Arabidopsis thaliana complement function in cytosol and mitochondria.
GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
UGA1 and UGA2, are subject to amino acid regulation as it occurs for UGA4.
Title: Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.
UGA1 and GAD1 were identified as aging genes.
Title: GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
UGA1 (GABA aminotransferase) transaminates only gamma-aminobutyrate and not beta-alanine.
Title: A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-aminobutyrate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-aminobutyrate transaminase activity	IEA Inferred from Electronic Annotation more info
enables 4-aminobutyrate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 4-aminobutyrate transaminase

NP_011533.3

EC 2.6.1.19

Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

525229..526644

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181148.3 → NP_011533.3 TPA: 4-aminobutyrate transaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011533.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A5H0J7, D6VUF4, P17649

UniProtKB/TrEMBL

A0A6L0ZKZ3, A6ZV09, B3LIJ9, B5VIY0, C7GK87, G2WEB0, N1P3S6

Conserved Domains (1) summary

TIGR00699
Location:5 → 468

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type