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    VAS1 valine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852986, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VAS1
    Official Full Name
    valine--tRNA ligase
    Primary source
    SGD:S000003326
    Locus tag
    YGR094W
    See related
    AllianceGenome:SGD:S000003326; FungiDB:YGR094W; VEuPathDB:YGR094W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific mRNA binding activity and valine-tRNA ligase activity. Involved in valyl-tRNA aminoacylation. Located in mitochondrion. Used to study combined oxidative phosphorylation deficiency 20; mitochondrial encephalomyopathy; mitochondrial metabolism disease; and myoclonic-atonic epilepsy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to several human genes including VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VAS1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (672186..675500)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase DBF2 Neighboring gene Drn1p Neighboring gene exosome non-catalytic core subunit RRP46 Neighboring gene thiamine transporter TPC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions of yeast valyl-tRNA synthetase with RNAs and conformational changes of the enzyme. Zaccaï G, et al. J Mol Biol, 1979 Apr 15. PMID 379352
    2. A tryptophan-rich peptide acts as a transcription activation domain. Lin CH, et al. BMC Mol Biol, 2010 Nov 16. PMID 21078206, Free PMC Article
    3. Stimulatory effect of ammonium sulfate at high concentrations on the aminoacylation of tRNA and tRNA-like molecules. Florentz C, et al. FEBS Lett, 1990 Feb 26. PMID 2178975
    4. The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases. Chatton B, et al. J Biol Chem, 1988 Jan 5. PMID 3275649
    5. Structure of the yeast valyl-tRNA synthetase gene (VASI) and the homology of its translated amino acid sequence with Escherichia coli isoleucyl-tRNA synthetase. Jordana X, et al. J Biol Chem, 1987 May 25. PMID 3294828

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables valine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    valine--tRNA ligase
    NP_011608.1
    • Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      672186..675500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181223.1 → NP_011608.1  TPA: valine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM6, P07806
      UniProtKB/TrEMBL
      A6ZV76, B3LID2, C7GWW9, C8Z8Y8, G2WEH9
      Conserved Domains (1) summary
      PTZ00419
      Location:128 → 1104
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07806.2

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