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    DED81 asparagine--tRNA ligase DED81 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856412, updated on 3-Nov-2024

    Summary

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    Official Symbol
    DED81
    Official Full Name
    asparagine--tRNA ligase DED81
    Primary source
    SGD:S000001061
    Locus tag
    YHR019C
    See related
    AllianceGenome:SGD:S000001061; FungiDB:YHR019C; VEuPathDB:YHR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables asparagine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in asparaginyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Used to study Charcot-Marie-Tooth disease and autosomal dominant distal hereditary motor neuronopathy. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DED81 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (141894..143558, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ysc83p Neighboring gene argininosuccinate lyase ARG4 Neighboring gene proline--tRNA ligase Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of YHR019 in Saccharomyces cerevisiae chromosome VIII as the gene for the cytosolic asparaginyl-tRNA synthetase. Landrieu I, et al. Yeast, 1998 Apr 30. PMID 9605503
    2. Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast. Thierry A, et al. G3 (Bethesda), 2016 May 3. PMID 26945028, Free PMC Article
    3. Comprehensive characterization of mRNAs associated with yeast cytosolic aminoacyl-tRNA synthetases. Garin S, et al. RNA Biol, 2021 Dec. PMID 34039240, Free PMC Article
    4. Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. Willis IM, et al. PLoS Genet, 2008 Jul 4. PMID 18604275, Free PMC Article
    5. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Richardson LA, et al. Cell Rep, 2012 Aug 30. PMID 22902402, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparagine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in asparaginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    asparagine--tRNA ligase DED81
    NP_011883.1
    • Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      141894..143558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179149.1 → NP_011883.1  TPA: asparagine--tRNA ligase DED81 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKW4, P38707
      UniProtKB/TrEMBL
      A6ZSS3, B3LSD9, C7GXA7, C8ZA86, N1P541
      Conserved Domains (1) summary
      COG0017
      Location:116 → 554
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38707.1

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