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    CIC1 Cic1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856449, updated on 7-Jul-2024

    Summary

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    Gene symbol
    CIC1
    Gene description
    Cic1p
    Primary source
    FungiDB:YHR052W
    Locus tag
    YHR052W
    See related
    SGD:S000001094; AllianceGenome:SGD:S000001094; VEuPathDB:YHR052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NSA3
    Summary
    Enables large ribosomal subunit rRNA binding activity; proteasome binding activity; and protein-macromolecule adaptor activity. Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and protein catabolic process. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RSL1D1 (ribosomal L1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CIC1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (210848..211978)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VI Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits. Fatica A, et al. RNA, 2003 Dec. PMID 14623999, Free PMC Article
    2. Structure and RNA recognition of ribosome assembly factor Utp30. Hu J, et al. RNA, 2017 Dec. PMID 28951391, Free PMC Article
    3. Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. Zhao Y, et al. G3 (Bethesda), 2014 Sep 17. PMID 25236733, Free PMC Article
    4. Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. Jäger S, et al. EMBO J, 2001 Aug 15. PMID 11500370, Free PMC Article
    5. Multicopy suppression screen in the msb3 msb4 Saccharomyces cerevisiae double mutant, affected in Ypt/RabGAP activity. Dechamps C, et al. Biotechnol Lett, 2005 Oct. PMID 16231214

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cic1p
    NP_011919.1
    • Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      210848..211978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179182.1 → NP_011919.1  TPA: Cic1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL01, P38779
      UniProtKB/TrEMBL
      A0A6A5PXQ6, A6ZSW0, C7GT92, G2WFC6, N1P226
      Conserved Domains (1) summary
      pfam00687
      Location:77 → 287
      Ribosomal_L1; Ribosomal protein L1p/L10e family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38779.1

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