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    ELO1 fatty acid elongase ELO1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853243, updated on 17-May-2024

    Summary

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    Gene symbol
    ELO1
    Gene description
    fatty acid elongase ELO1
    Primary source
    FungiDB:YJL196C
    Locus tag
    YJL196C
    See related
    SGD:S000003732; AllianceGenome:SGD:S000003732; VEuPathDB:YJL196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fatty acid elongase activity. Involved in fatty acid elongation, unsaturated fatty acid. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in corneal dystrophy; spinocerebellar ataxia type 34; and spinocerebellar ataxia type 38. Orthologous to several human genes including ELOVL1 (ELOVL fatty acid elongase 1); ELOVL2 (ELOVL fatty acid elongase 2); and ELOVL3 (ELOVL fatty acid elongase 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ELO1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (67850..68782, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene AAA family ATPase CDC6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of the first plant fatty acid elongase specific for Delta(6)-polyunsaturated fatty acids. Zank TK, et al. Biochem Soc Trans, 2000 Dec. PMID 11171159
    2. Fatty acid elongation in yeast--biochemical characteristics of the enzyme system and isolation of elongation-defective mutants. Dittrich F, et al. Eur J Biochem, 1998 Mar 15. PMID 9546663
    3. Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae. Toke DA, et al. J Biol Chem, 1996 Aug 2. PMID 8702485
    4. Elo1p-dependent carboxy-terminal elongation of C14:1Delta(9) to C16:1Delta(11) fatty acids in Saccharomyces cerevisiae. Schneiter R, et al. J Bacteriol, 2000 Jul. PMID 10850979, Free PMC Article
    5. A critical role for very long-chain fatty acid elongases in oleic acid-mediated Saccharomyces cerevisiae cytotoxicity. Wang Q, et al. Microbiol Res, 2018 Mar. PMID 29458843

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid elongase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, unsaturated fatty acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid elongase ELO1
    NP_012339.1
    • Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      67850..68782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181629.1 → NP_012339.1  TPA: fatty acid elongase ELO1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ6, P39540
      UniProtKB/TrEMBL
      A0A6L0Z4U9, C7GS17, C8ZB25, G2WGI2, N1P8P7
      Conserved Domains (1) summary
      pfam01151
      Location:58 → 303
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39540.1

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