PHO90 SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: PHO90
Gene description: SPX domain-containing inorganic phosphate transporter
Primary source: FungiDB:YJL198W
Locus tag: YJL198W
See related: SGD:S000003734; AllianceGenome:SGD:S000003734; VEuPathDB:YJL198W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables inorganic phosphate transmembrane transporter activity. Involved in phosphate ion transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A1 (solute carrier family 13 member 1); SLC13A2 (solute carrier family 13 member 2); and SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_012337.1

Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain