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    RCY1 Rcy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853226, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RCY1
    Official Full Name
    Rcy1p
    Primary source
    SGD:S000003740
    Locus tag
    YJL204C
    See related
    AllianceGenome:SGD:S000003740; FungiDB:YJL204C; VEuPathDB:YJL204C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNARE binding activity. Involved in early endosome to Golgi transport; endocytic recycling; and endocytosis. Located in Golgi apparatus; endosome; and site of polarized growth. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RCY1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (50629..53151, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nce101p Neighboring gene Prp21p Neighboring gene Ecm25p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. Wiederkehr A, et al. J Cell Biol, 2000 Apr 17. PMID 10769031, Free PMC Article
    2. Interaction of the phospholipid flippase Drs2p with the F-box protein Rcy1p plays an important role in early endosome to trans-Golgi network vesicle transport in yeast. Hanamatsu H, et al. J Biochem, 2014 Jan. PMID 24272750
    3. Localization and functional requirement of yeast Na+/H+ exchanger, Nhx1p, in the endocytic and protein recycling pathway. Kojima A, et al. Biochim Biophys Acta, 2012 Feb. PMID 22210050
    4. P4-ATPase endosomal recycling relies on multiple retromer-dependent localization signals. Jiménez M, et al. Mol Biol Cell, 2024 Oct 1. PMID 39110530,
    5. Endocytic uptake of fluorescence labelled DNA in yeast. Riechers SP, et al. J Basic Microbiol, 2010 Feb. PMID 20175124

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results reveal the involvement of Rcy1 in chromosome regulation and another regulatory pathway controlling the Cse4 level and activity.
      Title: The F-box Protein Rcy1 Is Involved in the Degradation of Histone H3 Variant Cse4 and Genome Maintenance.
    2. Ypt31/32 GTPases regulate the function of Rcy1 in the phosphorylation and/or ubiquitination of proteins that recycle through the Golgi
      Title: Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling.
    3. Ypt31p/32p-Rcy1p pathway regulates putative phospholipid translocases to promote formation of vesicles destined for the trans-Golgi network from early endosomes.
      Title: Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rcy1p
    NP_012331.1
    • F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      50629..53151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181637.1 → NP_012331.1  TPA: Rcy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ0, P39530, P39531, P87193
      UniProtKB/TrEMBL
      N1P376
      Conserved Domains (1) summary
      pfam07393
      Location:101 → 827
      Sec10; Exocyst complex component Sec10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39531.4

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