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    TUL1 ubiquitin-protein ligase TUL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853832, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TUL1
    Official Full Name
    ubiquitin-protein ligase TUL1
    Primary source
    SGD:S000001517
    Locus tag
    YKL034W
    See related
    AllianceGenome:SGD:S000001517; FungiDB:YKL034W; VEuPathDB:YKL034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in Golgi apparatus. Part of Dsc E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TUL1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (371829..374105)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Aim26p Neighboring gene UTP glucose-1-phosphate uridylyltransferase Neighboring gene putative hydrolase Neighboring gene Tti1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy. Yang X, et al. J Cell Biol, 2020 Mar 2. PMID 32045480, Free PMC Article
    2. A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Reggiori F, et al. Nat Cell Biol, 2002 Feb. PMID 11788821
    3. Intravacuolar membrane lysis in Saccharomyces cerevisiae. Does vacuolar targeting of Cvt17/Aut5p affect its function? Epple UD, et al. J Biol Chem, 2003 Mar 7. PMID 12499386
    4. Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway. McNatt MW, et al. Mol Biol Cell, 2007 Feb. PMID 17182850, Free PMC Article
    5. Ubiquitination of phosphatidylethanolamine in organellar membranes. Sakamaki JI, et al. Mol Cell, 2022 Oct 6. PMID 36044902

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Tul1 E3 ligase functions in protein homeostasis under non-stress conditions and support a role in protein quality control.
      Title: Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsc E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase TUL1
    NP_012890.1
    • Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      371829..374105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179600.1 → NP_012890.1  TPA: ubiquitin-protein ligase TUL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXQ1, P36096
      UniProtKB/TrEMBL
      B3LR52, N1P0P2
      Conserved Domains (1) summary
      COG5540
      Location:320 → 758
      COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36096.1

    Gene LinkOut

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