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    BCH2 Bch2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853898, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BCH2
    Official Full Name
    Bch2p
    Primary source
    SGD:S000001735
    Locus tag
    YKR027W
    See related
    AllianceGenome:SGD:S000001735; FungiDB:YKR027W; VEuPathDB:YKR027W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP50
    Summary
    Involved in Golgi to plasma membrane transport and fungal-type cell wall chitin biosynthetic process. Located in mitochondrion. Part of exomer complex. Colocalizes with trans-Golgi network transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BCH2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (491364..493661)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B subunit alpha Neighboring gene tRNA-Arg Neighboring gene Sap190p Neighboring gene histone-binding protein SET3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complex interactions of Chs5p, the ChAPs, and the cargo Chs3p. Rockenbauch U, et al. Mol Biol Cell, 2012 Nov. PMID 23015758, Free PMC Article
    2. Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. Wang CW, et al. J Cell Biol, 2006 Sep 25. PMID 17000877, Free PMC Article
    3. The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast. Barfield RM, et al. Mol Biol Cell, 2009 Dec. PMID 19812245, Free PMC Article
    4. The Functional Specialization of Exomer as a Cargo Adaptor During the Evolution of Fungi. Anton C, et al. Genetics, 2018 Apr. PMID 29437703, Free PMC Article
    5. The prion-like domain in the exomer-dependent cargo Pin2 serves as a trans-Golgi retention motif. Ritz AM, et al. Cell Rep, 2014 Apr 10. PMID 24656818

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chitin biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exomer complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bch2p
    NP_012952.3
    • Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      491364..493661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179817.3 → NP_012952.3  TPA: Bch2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012952.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX92, P36122
      UniProtKB/TrEMBL
      A6ZZZ1, B3LRB1, C7GNN2, N1P0H1
      Conserved Domains (1) summary
      pfam09295
      Location:92 → 564
      ChAPs; ChAPs (Chs5p-Arf1p-binding proteins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36122.1

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