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    ENT4 Ent4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850621, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ENT4
    Official Full Name
    Ent4p
    Primary source
    SGD:S000003961
    Locus tag
    YLL038C
    See related
    AllianceGenome:SGD:S000003961; FungiDB:YLL038C; VEuPathDB:YLL038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in protein localization to plasma membrane. Located in cytosol. Orthologous to several human genes including ENTHD1 (ENTH domain containing 1); EPN1 (epsin 1); and EPN2 (epsin 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ENT4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (65775..66518, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene membrane morphogenesis protein VPS13 Neighboring gene ubiquitin Neighboring gene E3 ubiquitin-protein ligase PRP19 Neighboring gene polynucleotide 5'-hydroxyl-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polarization of cell growth in yeast. Pruyne D, et al. J Cell Sci, 2000 Feb. PMID 10652251
    2. Functional analysis of six novel ORFs on the left arm of chromosome XII in Saccharomyces cerevisiae reveals two essential genes, one of which is under cell-cycle control. El-Moghazy AN, et al. Yeast, 2000 Feb. PMID 10649456
    3. Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport. Chidambaram S, et al. J Biol Chem, 2004 Feb 6. PMID 14630930
    4. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. Wendland B, et al. EMBO J, 1999 Aug 16. PMID 10449404, Free PMC Article
    5. Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Kebaara BW, et al. Nucleic Acids Res, 2009 May. PMID 19270062, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ent4p
    NP_013062.1
    • hypothetical protein; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      65775..66518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181858.1 → NP_013062.1  TPA: Ent4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXW8, Q07872
      UniProtKB/TrEMBL
      B3LTD5, C8ZCT6, G2WIF9, N1P1A4
      Conserved Domains (1) summary
      cd16994
      Location:15 → 132
      ENTH_Ent4; Epsin N-Terminal Homology (ENTH) domain of Yeast Ent4 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07872.1

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