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    DAK1 dihydroxyacetone kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854932, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DAK1
    Official Full Name
    dihydroxyacetone kinase
    Primary source
    SGD:S000004535
    Locus tag
    YML070W
    See related
    AllianceGenome:SGD:S000004535; FungiDB:YML070W; VEuPathDB:YML070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycerone kinase activity. Involved in cellular response to toxic substance and glycerol to glycerone phosphate metabolic process. Located in cytoplasm. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DAK1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (133475..135229)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG8 Neighboring gene tRNA-Arg Neighboring gene FACT complex subunit POB3 Neighboring gene RBR-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as 'non-fermentable'. Aßkamp MR, et al. Biotechnol Biofuels, 2019. PMID 31695748, Free PMC Article
    2. Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1. Lee H, et al. Biochem Biophys Res Commun, 2009 Nov 6. PMID 19715675
    3. Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenorhabditis elegans. Molin M, et al. Proteomics, 2007 Oct. PMID 17890650
    4. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin M, et al. Mol Microbiol, 2006 May. PMID 16677304
    5. Fragmentation of dihydroxyacetone kinase 1 from Saccharomyces cerevisiae indicates a two-domain structure. Molin M, et al. Proteomics, 2003 May. PMID 12748953

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gpx3 interacts with Dak1, alleviates dihydroxyacetone-mediated stress by upregulating Dak activity, and consequently suppresses advanced glycation endproducts formation.
      Title: Reduced formation of advanced glycation endproducts via interactions between glutathione peroxidase 3 and dihydroxyacetone kinase 1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycerone kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol to glycerone phosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydroxyacetone kinase
    NP_013641.1
    • Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      133475..135229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182429.1 → NP_013641.1  TPA: dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013641.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZA3, P54838
      UniProtKB/TrEMBL
      A6ZLZ5, C7GW06, G2WJY5, N1P0U3
      Conserved Domains (1) summary
      TIGR02361
      Location:5 → 581
      dak_ATP; dihydroxyacetone kinase, ATP-dependent
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54838.1

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