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    EUC1 Euc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855138, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EUC1
    Official Full Name
    Euc1p
    Primary source
    SGD:S000004717
    Locus tag
    YMR111C
    See related
    AllianceGenome:SGD:S000004717; FungiDB:YMR111C; VEuPathDB:YMR111C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Involved in protein-containing complex localization. Located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See EUC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (492404..493792, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene myosin 5 Neighboring gene hexadecenal dehydrogenase Neighboring gene Med11p Neighboring gene dihydrofolate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. Zhou W, et al. J Biol Chem, 2004 Jul 30. PMID 15166219, Free PMC Article
    2. A proteomic strategy for gaining insights into protein sumoylation in yeast. Denison C, et al. Mol Cell Proteomics, 2005 Mar. PMID 15542864
    3. Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance. Höpfler M, et al. EMBO J, 2019 Jun 3. PMID 31015336, Free PMC Article
    4. Global analysis of protein sumoylation in Saccharomyces cerevisiae. Wohlschlegel JA, et al. J Biol Chem, 2004 Oct 29. PMID 15326169
    5. Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. Albuquerque CP, et al. PLoS Genet, 2013. PMID 23935535, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Euc1p
    NP_013829.1
    • Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      492404..493792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182611.1 → NP_013829.1  TPA: Euc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZT4, Q04461
      UniProtKB/TrEMBL
      A6ZMG8, B3LM02, C7GW98, C8ZEW4, G2WKG1, N1P0B9
      Conserved Domains (1) summary
      pfam12550
      Location:296 → 385
      GCR1_C; Transcriptional activator of glycolytic enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04461.1

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