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    COG5 Golgi transport complex subunit COG5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855676, updated on 29-Jun-2024

    Summary

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    Gene symbol
    COG5
    Gene description
    Golgi transport complex subunit COG5
    Primary source
    FungiDB:YNL051W
    Locus tag
    YNL051W
    See related
    SGD:S000004996; AllianceGenome:SGD:S000004996; VEuPathDB:YNL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    API4; COD4
    Summary
    Involved in cytoplasm to vacuole transport by the Cvt pathway and intra-Golgi vesicle-mediated transport. Located in cytosol. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COG5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (532659..533870)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene cytochrome c oxidase subunit Va Neighboring gene uncharacterized protein Neighboring gene COPII subunit SFB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Ha JY, et al. Proc Natl Acad Sci U S A, 2014 Nov 4. PMID 25331899, Free PMC Article
    2. Detailed Analysis of the Interaction of Yeast COG Complex. Ishii M, et al. Cell Struct Funct, 2018 Jul 19. PMID 29899178, Free PMC Article
    3. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article
    4. Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. Fotso P, et al. J Biol Chem, 2005 Jul 29. PMID 15932880
    5. Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production. Huang M, et al. Proc Natl Acad Sci U S A, 2018 Nov 20. PMID 30397111, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi transport complex subunit COG5
    NP_014347.1
    • Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      532659..533870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182890.1 → NP_014347.1  TPA: Golgi transport complex subunit COG5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014347.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1C8, P53951
      UniProtKB/TrEMBL
      A0A8H4BX74, B3LNR2, B5VQZ0, C8ZGH7, N1NY12
      Conserved Domains (1) summary
      pfam10392
      Location:14 → 146
      COG5; Golgi transport complex subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53951.1

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