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    PCL1 Pcl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855427, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PCL1
    Official Full Name
    Pcl1p
    Primary source
    SGD:S000005233
    Locus tag
    YNL289W
    See related
    AllianceGenome:SGD:S000005233; FungiDB:YNL289W; VEuPathDB:YNL289W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HCS26
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including positive regulation of macroautophagy; regulation of cyclin-dependent protein serine/threonine kinase activity; and septin ring organization. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and incipient cellular bud site. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PCL1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (87897..88736)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mid1p Neighboring gene replication factor C subunit 3 Neighboring gene ncRNA Neighboring gene CCR4-NOT core subunit CAF40

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Andrews BJ, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1465410, Free PMC Article
    2. CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR). Carballar R, et al. J Mol Biol, 2020 Dec 4. PMID 33217428
    3. The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. He F, et al. PLoS One, 2015. PMID 25860339, Free PMC Article
    4. Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation. Nishizawa M, et al. Mol Biol Cell, 1998 Sep. PMID 9725902, Free PMC Article
    5. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Ogas J, et al. Cell, 1991 Sep 6. PMID 1832336

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pcl1p
    NP_014110.1
    • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      87897..88736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183127.1 → NP_014110.1  TPA: Pcl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q4, P24867
      UniProtKB/TrEMBL
      A6ZSI9, B3LPC7, B5VQC8, C7GS52, C8ZGN2, G2WLH8, N1NWW7
      Conserved Domains (1) summary
      cd20557
      Location:54 → 149
      CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24867.1

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