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    MRX6 Mrx6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855421, updated on 9-Jun-2024

    Summary

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    Gene symbol
    MRX6
    Gene description
    Mrx6p
    Primary source
    FungiDB:YNL295W
    Locus tag
    YNL295W
    See related
    SGD:S000005239; AllianceGenome:SGD:S000005239; VEuPathDB:YNL295W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial nucleoid organization and regulation of mitochondrial DNA metabolic process. Located in mitochondrial matrix. Colocalizes with mitochondrial chromosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRX6 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (76946..78520)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CLA4 Neighboring gene Mon2p Neighboring gene Rim21p Neighboring gene Rab GTPase-activating protein MSB3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Göke A, et al. Mol Biol Cell, 2020 Mar 19. PMID 31532710, Free PMC Article
    2. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
    3. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
    4. Genomewide screen reveals a wide regulatory network for di/tripeptide utilization in Saccharomyces cerevisiae. Cai H, et al. Genetics, 2006 Mar. PMID 16361226, Free PMC Article
    5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial nucleoid organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mrx6p
    NP_014104.1
    • Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      76946..78520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183133.1 → NP_014104.1  TPA: Mrx6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0P8, P48564
      UniProtKB/TrEMBL
      A0A8H4BWC5, A6ZSI3, C7GS57
      Conserved Domains (1) summary
      pfam08692
      Location:111 → 242
      Pet20; Mitochondrial protein Pet20
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48564.1

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