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    CMK2 calmodulin-dependent protein kinase CMK2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854144, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CMK2
    Official Full Name
    calmodulin-dependent protein kinase CMK2
    Primary source
    SGD:S000005376
    Locus tag
    YOL016C
    See related
    AllianceGenome:SGD:S000005376; FungiDB:YOL016C; VEuPathDB:YOL016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to several human genes including CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CMK2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (294777..296120, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tlg2p Neighboring gene Esc8p Neighboring gene Irc10p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae protein kinase dependent on Ca2+ and calmodulin. Miyakawa T, et al. J Bacteriol, 1989 Mar. PMID 2537817, Free PMC Article
    2. Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. Pausch MH, et al. EMBO J, 1991 Jun. PMID 2026147, Free PMC Article
    3. Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2. Ohya Y, et al. J Biol Chem, 1991 Jul 5. PMID 2061341
    4. Calmodulin kinase 2 genetically interacts with Rch1p to negatively regulate calcium import into Saccharomyces cerevisiae after extracellular calcium pulse. Coleman CE, et al. Arch Microbiol, 2022 Jul 24. PMID 35871646
    5. Vacuolar H+-ATPase (V-ATPase) promotes vacuolar membrane permeabilization and nonapoptotic death in stressed yeast. Kim H, et al. J Biol Chem, 2012 Jun 1. PMID 22511765, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsp90 prevented the death of calcineurin- and Cmk2-deficient cells.
      Title: Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation HDA PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-dependent protein kinase CMK2
    NP_014626.1
    • Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      294777..296120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183270.1 → NP_014626.1  TPA: calmodulin-dependent protein kinase CMK2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W250, P22517
      UniProtKB/TrEMBL
      A6ZNJ1, B3LJ41, B5VRN9, C7GQW6, C8ZHU8, N1NWD9
      Conserved Domains (2) summary
      smart00220
      Location:47 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05117
      Location:46 → 308
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22517.2

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