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    ESC8 Esc8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854143, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ESC8
    Official Full Name
    Esc8p
    Primary source
    SGD:S000005377
    Locus tag
    YOL017W
    See related
    AllianceGenome:SGD:S000005377; FungiDB:YOL017W; VEuPathDB:YOL017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in heterochromatin formation and sister chromatid cohesion. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ESC8 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (292529..294673)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tos7p Neighboring gene Tlg2p Neighboring gene calmodulin-dependent protein kinase CMK2 Neighboring gene Irc10p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8. Cuperus G, et al. Genetics, 2002 Oct. PMID 12399377, Free PMC Article
    2. Determinants of Sir2-Mediated, Silent Chromatin Cohesion. Chen YF, et al. Mol Cell Biol, 2016 Aug 1. PMID 27185881, Free PMC Article
    3. The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis. Chu DB, et al. Genetics, 2017 Jul. PMID 28455351, Free PMC Article
    4. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article
    5. A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Krogan NJ, et al. Mol Cell, 2003 Dec. PMID 14690608

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Esc8p
    NP_014625.1
    • Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      292529..294673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183271.1 → NP_014625.1  TPA: Esc8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W249, Q08119
      UniProtKB/TrEMBL
      A6ZNJ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08119.1

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