TAT2 aromatic amino acid transmembrane transporter TAT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TAT2
Gene description: aromatic amino acid transmembrane transporter TAT2
Primary source: FungiDB:YOL020W
Locus tag: YOL020W
See related: SGD:S000005380; AllianceGenome:SGD:S000005380; VEuPathDB:YOL020W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HPG2; LTG3; SAB2; SCM2; TAP2
Summary: Enables high-affinity tryptophan transmembrane transporter activity. Involved in tryptophan transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TAT2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (286172..287950)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
Title: Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae, stabilizes amino acid permeases.
Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
Tup1p bound to TAT1 and TAT2 gene promoters, which depended on Stp1/2p activators.
Title: Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
Fifteen amino acid residues in Tat2 transmembrane domains 1, -3, -5, -8, and -10 are responsible for tryptophan uptake.
Title: Structural and functional implications of the yeast high-affinity tryptophan permease Tat2.
Data show that tryptophan transport is increased in pdr5Delta/yor1 strains and reduced in rsb1Delta cells, and the localization and vacuolar degradation of Tat2 were affected in these genetic backgrounds.
Title: Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.
Sna3 is a potential competitor of Bul1 for the Rsp5 WW domain affecting degradation of tryptophan permease Tat2.
Title: Overexpression of Sna3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1.
Here, it is shown that the deletion in ERG2, which encodes sterol C8-C7 isomerase (the next enzymatic step after Erg6), promotes the vacuolar degradation of Tat2.
Title: Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant.
GPI-anchored proteins are required for the recruitment of membrane proteins Tat2p and Fur4p to the plasma membrane via detergent-resistant membranes.
Title: Glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins Tat2p and Fur4p.
multiple ubiquitin-specific proteases are involved in hydrostatic pressure-induced degradation of Tat2, rather than free ubiquitin depletion.
Title: Multiple ubiquitin-specific protease genes are involved in degradation of yeast tryptophan permease Tat2 at high pressure.
cytoplasmic tails are involved in Rsp5-mediated ubiquitination of Tat2 under high-pressure or low-temperature conditions
Title: The N- and C-terminal mutations in tryptophan permease Tat2 confer cell growth in Saccharomyces cerevisiae under high-pressure and low-temperature conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables high-affinity tryptophan transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in eisosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aromatic amino acid transmembrane transporter TAT2

NP_014622.1

High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

286172..287950

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183274.1 → NP_014622.1 TPA: aromatic amino acid transmembrane transporter TAT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014622.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W245, P38967

UniProtKB/TrEMBL

A0A8H4BUM4, A6ZNI6, B3LJ36, C7GVE9, C8ZHU3

Conserved Domains (1) summary

COG0833
Location:52 → 591

LysP; Amino acid permease [Amino acid transport and metabolism]