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    RGA1 GTPase-activating protein RGA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854294, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RGA1
    Official Full Name
    GTPase-activating protein RGA1
    Primary source
    SGD:S000005653
    Locus tag
    YOR127W
    See related
    AllianceGenome:SGD:S000005653; FungiDB:YOR127W; VEuPathDB:YOR127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DBM1; THE1
    Summary
    Enables GTPase activator activity. Involved in several processes, including axial cellular bud site selection; budding cell apical bud growth; and cytoskeleton organization. Located in cellular birth scar; cellular bud neck split septin rings; and cellular bud scar. Orthologous to several human genes including ARHGAP12 (Rho GTPase activating protein 12) and ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RGA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (561170..564193)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative monooxygenase CAT5 Neighboring gene isoamyl acetate-hydrolyzing esterase Neighboring gene phosphoribosylaminoimidazole carboxylase ADE2 Neighboring gene Afi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of the Cdc42 GTPase limits the replicative life span of budding yeast. Kang PJ, et al. Mol Biol Cell, 2022 Apr 1. PMID 35044837, Free PMC Article
    2. Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. Tong Z, et al. J Cell Biol, 2007 Dec 31. PMID 18166650, Free PMC Article
    3. The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Chen GC, et al. Mol Cell Biol, 1996 Apr. PMID 8657111, Free PMC Article
    4. Regulation of Cdc42 polarization by the Rsr1 GTPase and Rga1, a Cdc42 GTPase-activating protein, in budding yeast. Lee ME, et al. J Cell Sci, 2015 Jun 1. PMID 25908844, Free PMC Article
    5. The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. He F, et al. PLoS One, 2015. PMID 25860339, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in budding cell isotropic bud growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of pseudohyphal growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular birth scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular bud IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck split septin rings IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein RGA1
    NP_014770.1
    • GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      561170..564193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183546.1 → NP_014770.1  TPA: GTPase-activating protein RGA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2I5, P39083, P39934
      UniProtKB/TrEMBL
      A6ZNX4, C7GML2, N1NWM0
      Conserved Domains (4) summary
      cd09394
      Location:13 → 67
      LIM1_Rga; The first LIM domain of Rga GTPase-Activating Proteins
      cd09395
      Location:70 → 123
      LIM2_Rga; The second LIM domain of Rga GTPase-Activating Proteins
      smart00324
      Location:803 → 1002
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      COG1196
      Location:569 → 673
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39083.1

    Gene LinkOut

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