SNC2 SNAP receptor SNC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SNC2
Gene description: SNAP receptor SNC2
Primary source: FungiDB:YOR327C
Locus tag: YOR327C
See related: SGD:S000005854; AllianceGenome:SGD:S000005854; VEuPathDB:YOR327C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables SNAP receptor activity. Involved in several processes, including Golgi to plasma membrane transport; exocytosis; and vesicle fusion. Located in endosome; trans-Golgi network; and transport vesicle membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to several human genes including VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SNC2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (930734..931081, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
Title: The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.
Using EPR, determination of the structure of the transmembrane domain (TMD) of the vesicle (v)-SNARE Snc2p involved in trafficking in yeast
Title: Hemifusion in SNARE-mediated membrane fusion.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IPI Inferred from Physical Interaction more info	PubMed
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cell periphery	HDA more info	PubMed
located_in cellular bud	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SNAP receptor SNC2

NP_014972.3

Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

930734..931081 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183747.3 → NP_014972.3 TPA: SNAP receptor SNC2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014972.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W324, P33328

UniProtKB/TrEMBL

A0A6A5Q6M9, A6ZPF9, B3LJY8, C7GNT7, C8ZH78, G2WNJ1, N1NYY7

Conserved Domains (1) summary

COG5143
Location:1 → 96

SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]