CLN2 cyclin CLN2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CLN2
Official Full Name: cyclin CLN2
Primary source: SGD:S000006177
Locus tag: YPL256C
See related: AllianceGenome:SGD:S000006177; FungiDB:YPL256C; VEuPathDB:YPL256C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in re-entry into mitotic cell cycle after pheromone arrest; regulation of protein phosphorylation; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CLN2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (64977..66614, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae.
Title: G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae.
Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast.
Title: Differential Scaling of Gene Expression with Cell Size May Explain Size Control in Budding Yeast.
Pho85 and Pho4 regulated CLN2 expression under alkaline condition.
Title: The regulators of yeast PHO system participate in the transcriptional regulation of G1 cyclin under alkaline stress conditions.
A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.
Title: A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry.
The region between amino acids 225 and 299 of Cln2 is sufficient to confer Cln2-specific functionality to Cln1.
Title: Molecular basis of the functional distinction between Cln1 and Cln2 cyclins.
Ime2 does not directly catalyze Sic1 phosphorylation to target it for destabilization as Cln1,-2/Cdk1 do during the cell cycle
Title: Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.
We carried out a focused study on a physiologically important nucleosome-depleted regions in the yeast CLN2 promoter. Eight conserved factor binding sites, including that of Reb1, Mcm1, and Rsc3, that cause the local nucleosome depletion, were identified.
Title: Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter.
Reporter assays show that both activities appear to depend on the 5'-untranslated region of CLN2 mRNA and that Ssd1p binds to this region via its amino- and carboxy-terminal domains.
Title: Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5'-untranslated region of CLN2 mRNA.
analysis of NDR- or nucleosomal-localized SCB sites driving Cln2 expression
Title: Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle.
Forced periodic expression of the G(1) cyclin CLN2 phase locks the cell cycle of budding yeast over a range of extrinsic periods in an exponentially growing monolayer culture.
Title: Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in re-entry into mitotic cell cycle after pheromone arrest	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in traversing start control point of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in traversing start control point of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in traversing start control point of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin CLN2

NP_015067.1

G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

64977..66614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184070.1 → NP_015067.1 TPA: cyclin CLN2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015067.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3B5, E9P938, P20438

UniProtKB/TrEMBL

B3LKH6, B5VST1, C7GTR3, C8ZIC2, N1P1M4

Conserved Domains (1) summary

COG5024
Location:33 → 524

COG5024; Cyclin [Cell division and chromosome partitioning]